ENTRAIN-Vision brings together leading experts from all key disciplines relevant for visual restoration covering the fields of neuroscience, engineering, physiology, pathology, medicine, AAV production neuroinformatics, machine learning, and computational modeling.
The research programme focuses on the development of new innovative technologies for visual restoration at both the retinal and cortical levels. Innovation is required to generate new technologies allowing greater visual acuity with either electronic prostheses or optogenetic therapy. These technologies will first be assessed on blind rodents by functional measurements including behavioral tests to then evaluated in larger animals preparing thereby the translation to human patients. In this clinical translation, computational modeling will be performed to properly design the stimulation protocols. Finally, clinical endpoints for the validation of such innovative technologies will be defined.
The researche programme is divided in 7 workpackages:
> WP1: Visual Restoration by Prosthesis: preclinical validation
> WP2: Visual Restoration by chemical and biological photoswitches: preclinical validation
> WP3: From natural vision to model for artificial vision
> WP4: Visual perception during retinal diseases in animal models and patients
> WP5: Training & Dissemination
> WP6: Managment